Originally Posted by FrodeSolheim

Well, there's a couple of problems with your setup there:
- The quotes must be skipped, and ~ cannot be used there (this is not a shell).
- If you're using FS-UAE Launcher, it won't pick up that anyway.

There's a new way in FS-UAE 2.2.x which also works fine with FS-UAE Launcher, just see http://fs-uae.net/paths ("Base Directory") for more information.