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To invoke DEC again....
The DEC VMS operating systems development toolchain includes this.
The original version of VMS ran on a machine called the VAX, a 32bit memory-to-memory CISC machine which was later superseded by the 64bit Alpha, a 64bit register-to-register RISC machine.
The VMS assembler is called MACRO, when they ported to Alpha, they kept it and released it as MACRO32, a compiler generating Alpha code (with limitations such as user-mode only code and no 64bit pointers)
In addition you got MACRO64 for writing /real/ Alpha code.
To what extend MACRO32 does optimization i'm not sure, i never wrote code in it, but from what i understand it uses the same DEC compiler backend as the other languages (C/C++, Pascal, Fortran etc)
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