You only need to use the .INI file if you don't like registry entries... choose one of the two methods...
With the file "
WinUAE_v4.0.0_Registry.rar", extract somewhere, then double-click on the "
WinUAE.reg" file, select "
Yes" and then "
OK" to replace the old registry settings
With the "
WinUAE_v4.0.0_INI.rar" file, extract into "
C:\WinUAE"