Hi, that should indeed by possible.
I've seen that -10810 error before. Please go into System Preferences -> Security & Privacy ->Privacy tab -> Files and Folders and check the FS-UAE Launcher has access to "Documents Folder".
(If you answered no to allow access the Documents folder when first running, the Launcher will fail with that error code)
Re: quarantine: Could be that it is normal with quarantine attr after the app has been "approved" to run. On my 10.15 system where there seems to some flags in the quarantine attrs which change from 0181 to 01c1 when the app is first launched (and allowed to run).
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