Hmm I have never owned a pc so i dont know much about the new ones, but my favourites are:
Monkey Island 1 - 2 : Extremely funny and cool games ..
Lure of The Temptress: Another classic, very nice atmosphere ..
Simon The Sorcerer: Great gfx, lots of funny talking and a really cool story!
Other adventure games: Loom, Curse Of Enchantia, Willy Beamish, The Larry series and ofcourse Space Quest ..