Sas/C is the most Amiga friendly, relatively easy to use (once you know how to setup a new project).
Vbcc is good with standards and easy to setup ; also actively maintained.
Gcc is for Unix stuff ; generates its own object format and not generally user friendly (but is supposed to produce good code).
HiSoft cpp has integrated IDE, is very friendly, compiles fast, but not good with current standards and sometimes a little on the buggy side.
I don't usually code in C (especially not for Amiga apps) and my typical use is to compile current code and then step-by-step convert into handwritten asm.
But if faced the need to write portable code i'd use VS2015 to make it work, then vbcc to build the 68k version.
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