Depends on block size and number of buffer I think.
I would make at least three or four partitions so that each partition has enough space to take a backup of the other partitions.
Sometimes errors occur which just cannot be repaired, so it might be needed to backup / format / restore. In this case it's better to have smaller partitions and enough spare space to store the backup.
Also with partitions bigger than 2GB you will get side effects like programs refusing to install because not enough space is available although there is plenty.
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