I tried MUI5 a while back and compatibility was dreadful. I was getting all kinds of screen corruption issues and programs failing. To be fair, I'd had trouble with my ZZ9000 too, but even so it just wasn't worth the slowdown for me, and this is on an 060/50.
Ultimately everything works on 3.8, so there's very little value in upgrading unless you're emulating and want shiny new looks. If you want shiny new looks, I'm not sure an Amiga is the best platform.
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