F12 brings up the WinUAE window - This is the main button. It's your baby
Keyboard Layout A -
Numpad 8 = Up
Numpad 6 = Right
Numpad 4 = Left
Numpad 2 = Down
Numpad 0 = Button
Keyboard Layout B -
Cursor Keys for directional movement
Right CTRL (Both?) = Button
Keyboard Layout C -
No idea. I never use it
Note: When using Keyboard Layout B and you need the cursor keys to do something in a game, you're screwed (thats when you switch keyboard layouts)