What you want is some removable drive bays like this one
www.ebay.co.uk/itm/190368771301
I have 2 in each of my Amiga towers and one in my PC. Now I never have to open the cases to change hard drives or CF cards. Just make sure you power off before you pull them out or put them in, I have a 40 pin IDE to CF adapter in one of them and an assortment of hard drives in the rest. When you plug them into the PC bay you can then access them in WinUAE directly.
Couple of cheap adapters and you can use 2.5" hard drives in them as well as 3.5" ones. Best solution i've found.