It is practically never anything to do with sound emulation or hardware.
Most common causes are:
- aggressive power saving (approximate/cycle-exact modes use physical CPU time in very short bursts. Test if fastest possible CPU makes any difference)
- display rendering being too slow (forced vsync etc..). Check if windowed mode/fullscreen/D3D9/D3d11 changes make any difference.
- too slow CPU (not in this case, unless it is overheating and throttling)
AE-5 is good, it also supports quite low buffer sizes.
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