I had this issue too. What I did was
1) go to the location of the game via the folders.
2) remove the "+" from the game name (icon view).
3) Right click the game icon, go to information, then remove the + from the part it points to the internationalkarate+.slave then save that.
4) change the folder views so it lists all files and folders. rename the slave file to internationalkarate.slave
5) then try running the game to see if it works. If all ok then update the iguide to reflect what you done.