Do you mean extra large ADF like HDF? I think It might be possible but would require a mount list as well as a patched trackdisk.device.
I had a tiny play under winuae with Aros trackdisk.device with some help from prowler -
IIRC I always got seek error: on last track during formating but seemed to work ish
:but track 40 is no longer Root Block and disk is now Not Dos - but maybe with just mount list it be possible....?
...SIMCD32 is probably best for running CD32/CDTV games from iso