Tried the reset, also unplug 5v line, also unplug all and reconnect.. I have soldered pins and the programming mode is ON. Also have a jumper on DS0.
I got back to "Failed to get init ACK from device" again...
If I check dmesg, it just says "PL-2303/X V1.5.1 start, Prolific" (I'm on OS X 10.9.2 Mavericks).