Nope, switching between sync/async would mean changing clock frequencies on the fly. That's even more complicated and error prone. The result would be an extremely expensive design that doesn't deliver enough added performance to justify the cost.
No cables. Although the 86-pin CPU port is not really a high-speed bus, you can't just take the design and expect it to work on a cable, where you have signal reflections and crosstalk. Try it if you want, but don't expect any help from my side if it doesn't work.