there's one cute game on MegaDrive which has that Amiga feeling. It's Flink, which on Amiga platform was released for CD32 only. Another evidence that MD could handle games that were not possible on A500.
Besides I'd risk statement that MD+MegaCD could crunch quite a data - take a look at smooth scaling and rotation in AH3 Thunderstrike (Thunderhawk in Europe), Jaguar XJ 220 or Batman Return's driving/flying levels, which make CD32's performance look pale. Go compare Thunderstrike with Gunship 2000