Just to clarify: we have three issues here.
1, compatibility of the original game with various Amiga models
2, compatibility of any given drive (if modified for internal Amiga use)
3, incompatibility of Escom produced Amiga models due to missing drive signals
None of these have anything to do with KryoFlux - however if you actually want to use the original games written, you should really consider these things.
The only thing that does have effect on KryoFlux usage is the precision of the speed and signals of the drive being used to write the disk with KryoFlux plus the quality of the disk used.