Yeah of course, because Guitar Hero is a Klax clone, not the other way around
Seriously though, I think it would be great to make our own new OCS Guitar Hero clone, but different to Tracker Hero. I think we could use pre-recorded music as 8SVX samples rather than mods, and fill it with independent music from musical artists online.
Of course it would be a big download and would have to be HDD/CD-only, but it's totally doable with the Amiga's hardware. A dancing game that uses a vector shaped dancer on the background playfield with the direction arrows moving up or down the screen on the front playfield could work too.