Make the next AmigaOS for a specific Intel/AMD motherboard, and a specific gfx card (Radeon 1400, for example) and a specific soundcard. Stuff a "kickstart" on an addon PCI-card (in muchly the same manner as a SCSI card).
That way, we "only" need a small set of drivers, which will also work, although not as well, on better than minimum spec hardware.
Throw in an integrated (almost seemless) UAE for fairly good backwards compatability with our 3.9 and earlier software. At least, with hardware thus costing in the vicinity of £250 - £300, it's something "everyone" can afford, and it can even run native Windows if we need to use anything alien.