Lastnight I got the Megadrive emulator working for my Wii, and tried a few games out. I'd never really seen many games on the Megadrive before, so it was interesting to see how they compared to the Amiga.
The sound is definitely weaker! And takes the edge off quite a few games. Some titles seem quite competitive with the Amiga on graphics i.e. Speedball II and Marble Madness. But quite a lot of other have strange graphics that look a bit "dirty". Pacmania is the worst, the colour palette is really bad. I was surprised to see Sword of Sodan on the Megadrive, but it was poor compared to the Amiga version.
Sonic is impressive though, I have to say.