@Akira: I wouldnt be using this version FOL has attached in the first post. Go to pspuae.com and get the latest version. Also have a poke around on the forums over there, the lads have gone to some effort with their "ram save states"
I am not the right person to be giving config tips as I never gave PSPUAE enough time, even when I was given beta tester status.
You will find though that some games run better than others with different settings. There is no "one size fits all" super config. Experiment or see if someone has created a WHDLoad "ram save state" of your favourite games.