Cadaver would be tougher because of isometric stuff I'm not familiar with, object interaction, but there's no or very few A.I. for the enemies and the game could be remade perfectly I think.
But we're talking science fiction here
Yeah Cadaver is a piece of work. Even with the work I've done in my Last Ninja 2 remake, there are still a lot of things in it that completely leave me stumped how they pulled it off on an Amiga. Multiple layers, 100% accurate collision detection and depth sorting... Even the objects have isometric depth. Methinks that they painstakingly gave every object isometric collision box information by hand, I don't see how else you can give a 2D object 3D depth.
The idea of building an editor for it alone gives me a head ache.