That is an interesting idea. If you could get a DVD-Rom drive to work in a CD64 or V64 then think how many more games you could fit on a disc.
I did some searching and some have reported that it is possible. You would need a DVD-Rom drive that supports DOS mode, then it should work. However some report that you would also need to give the drive its own power source due to DVD drives needing much more than CD drives to function.