oh you guys are going to love the newer DRM protection in the CPU, GPU and motherboard for newer IBM PC compatibles and the Vista operating system.
I think the XBOX 360 is already a good step towards 'uncrackable' software. True there will always be the hardware gurus who will figure out a work around, but when it's too hard for the mainstream users to continually patch/hack/reconfigure their hardware just to play a game, then the battle is won.
Piracy was killing the Amiga, years before Commodore's inept management did. Why would software developer's release stuff on a machine where it'd be copied and they'd get little/no return - when they could release it on Megadrive/SNES and have less issues with piracy (because not everyone had a cartridge copier or loader back then).