I hope you're all aware of the up and coming followups to the classic amiga games?
Geoff Crammond is supposed to be working on Stunt Car Racer Pro, an official sequel to the classic title. Haven' heard much about that one lately.
Sid Meier's Pirates! will be released for Xbox and PC in November.
Giana Sisters already have an unofficial sequel with updated graphics, but still 2D. It's called Giana Returns or something and there should be a Dreamcast version and a couple of other versions. I only tried the Dreamcast version, and I think it's great. Still the first one that's the best too.
Other than that, we all know the actual sequel to Giana Sisters is Hard'n'Heavry.