For non enthusiasts
I still like the easy interphase of musicline .
okay soits not an over complex GUI but its two basic pages allows fast creation via your miggy keyboard and the loading of sound sample sets is easy.
Obviously OCTOMED sound studio is the Daddy because it also allows your midi conections to be used , but it tends to over quantise everything , unlike bars & Pipes , or Camouflage.
But if your just talking EMU nexi then Akira has given you the best advice
By the way if you want to upload me your tunes my scarey & perverse deadwood site is now open , try not to look anywhere else and head for the guest tunes forum box
It will be up in 10 minutes