I think we have different priorities (after all, if I was only interested in convenience then I'd stick with WinUAE, which I'm actually very fond of).
But really good to know about OpenC64MegaDrivePadAdapter! From the readme it does sound like the Amiga can safely use the Mega Drive controller regardless though?
I actually don't mind UP for jump so much, so I'm more just concerned with safety, especially if third party options (e.g. Quickshot pads) might be slightly different electrically to the official Sega pads.
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