Some nice options with the Raspberry Pi/Ami-hybrid, Un-Amiga and MiSTix boards. What I think would be really cool would be an Amy-ITX style board that takes the A500 chipset but with two Raspberry Pi type GPIO headers with built in pistorm and Amiga Digital Video interfaces.
pistorm project
https://github.com/captain-amygdala/pistorm
Amiga Digital Video project
https://github.com/c0pperdragon/Amiga-Digital-Video
You have a real chipset for Amiga feel but the advantages of over 200MIPS emulated processor speed, emulated IDE, lots of RAM, HDMI output and other "hybrid" possibilities in the future.