No, they will not run "natively" on the Amiga.
The Amiga version of ShapeShifter i.e. the MAC emulator, is required
Sort of the same as with
Day Of The Tentacle in my collection, the Amiga version of ScummVM by NovaCoder is needed to play the game.
Edit: that reminds me, maybe I might add Sam & Max Hit the Road via ScummVM...