This seems to run ok on Amithlon, but I can't verify as I have yet to figure out how to create a working 320x240 Picasso96 screen mode.
When I start a game I can hear it playing, but out of sync message displayed on my monitor.
My next mission in life = get a working 320x240 screen mode....
Update: done a bit of investigation and you need a monitor that supports QVGA. I switched to my Microvitec Multisync and 320x240 works
Other games work fine with 320x240 screenmode (ADoom, Heretic, Hexen etc) but ScummVM is all squashed at the top of the screen. Not usable at all
However, VGA games like Curse of Monkey Island are perfect and full speed