It can be done with ISOmount but, as Nobby_UK pointed out, it only works for Dos disks and you can only boot from the disk, you can't swap disks.
As mentioned before it's best to get a Gotek, all your ADF's on one USB stick.
The HXC is better IMO but costs more. (You get what you pay for)
I can't remember if the Hermes firmware boots NDOS disks or it's the HXC firmware that does, or maybe it's both.